COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Análise da Ponte Luiz I com vista à utilização pelo Metro Ligeiro do Porto

A comunicação, o trabalho em equipa, a resolução de problemas e as capacidades críticas ecriativas são cada vez mais importantes na sociedade da informação. Por esse motivo, oconstrutivismo tem tomado um papel cada vez mais relevante no ensino, que privilegia agoraas capacidades e os processos mentais dos alunos e não tanto a memória.Os webquests apresentam uma boa solução de apoio a este método de ensino: requeremesforços de procura, análise e síntese, desenvolvendo processos cognitivos simultâneos àaquisição de conhecimento. Por outro lado, a sua relevância reside também no facto de serconstruído e talhado especialmente para cobrir áreas curriculares relativamente às quais osprofessores geralmente sentem lacunas em termos de material didáctico auxiliar.Neste artigo pretende-se demonstrar as potencialidades desta ferramenta, quer no ensinopresencial quer no ensino à distância

Biological Maturation, Body Morphology and Physical Performance in 8-16 year-old obese girls from Montes Claros - MG

Measurements of maturity depend on the biological system considered since differences are often found in performance and body size in subjects of the same chronological age. The objective of this study was to identify associations between biological maturation, body morphology and physical performance in girls aged from 8.0 to 15.9 year-old and to verify the bone age in obese girls and compare it with chronological age. For that purpose 2040 (11.9 ± 2.3 years) school girls from Montes Claros, participated in this study. Regular anthropometric measures as height and body mass were taken. Triceps, biceps, subscapular, abdominal, suprailiac and calf skinfolds were also registered. Physical performance was assessed trough the test of a standing long jump, handgrip strength and 20 m multistage shuttle run. Maturational status, the average age at menarche and identification of PHV (maturity off set) were determined by means of the retrospective method. Girls with the BMI above the 95th percentile got their bone age evaluated through X-ray of the left hand/wrist, in accordance with the FELS method. It was possible to find an average age at menarche of 11.30 ± 0.70, while the average age at PHV was 12.17 ± 0.71 years of age. It was observed that both body composition and physical performance showed a tendency to increase with advancing age. However, when controlling the effect of maturation, despite having higher values in body composition the post-menarche girls group did not show higher levels of physical performance. In all age groups, obese girls showed mean rates of bone age higher than chronologic age (12.25 ± 2.09 and 14.09 ± 2.35, respectively, p=0.000). Chronological age should be used with caution when evaluating obese teenagers as it may underestimate biological age

Youth soccer players, 11-14 years: Maturity, size, function, skill and goal orientation

Background: Participants in many youth sports are commonly combined into age groups spanning 2 years. Aim: The study compared variation in size, function, sport-specific skill and goal orientation associated with differences in biological maturity status of youth soccer players within two competitive age groups. Methods: The sample included 159 male soccer players in two competitive age groups, 11-12 years (n=87) and 13-14 years (n=72). Weight, height, sitting height and four skinfolds, four functional capacities, four soccer skills and goal orientation were measured. Skeletal maturity was assessed using the Fels method. Each player was classified as late, on time or early maturing based on the difference between skeletal and chronological ages. ANOVA was used to compare characteristics of players across maturity groups. Results: Late, on time and early maturing boys are represented among 11-12-year-olds, but late maturing boys are under-represented among 13-14-year-olds. Players in each age group advanced in maturity are taller and heavier than those on time and late in skeletal maturity, but players of contrasting maturity status do not differ, with few exceptions, in functional capacities, soccer-specific skills and goal orientation. Conclusion: Variation in body size associated with maturity status in youth soccer players is similar to that for adolescent males in general, but soccer players who vary in maturity status do not differ in functional capacities, soccer-specific skills and goal orientation